Prognostic value of a left atrioventricular coupling index (LACI) in pre- and post-menopausal women. from the multi-ethnic study of atherosclerosis (MESA)

Abstract Background Endogenous sex hormones associated with both the left atrial (LA) and ventricular (LV) structures in peri-menopausal women, but association of menopause status atrioventricular coupling is not well established. Purpose To assess prognostic value a index (LACI) pre- post-menopausal women without history cardiovascular disease (CVD) at baseline Multi-Ethnic Study Atherosclerosis (MESA). Methods In participating MESA study, LACI was measured as ratio end-diastolic volume to using magnetic resonance (CMR). Cox proportional hazard models were used between outcomes fibrillation (AF), heart failure (HF), hard CVD defined by myocardial infarction, resuscitated cardiac arrest, stroke, or coronary death. Results Among 2,087 participants (61±10 years), 485 events observed during mean follow-up period 13.2±3.3 years. A higher independently AF (HR 1.70; 95% CI [1.51–1.90]), HF 1.62; [1.33–1.97]), 1.30; [1.13–1.51], all p<0.001). Adjusted showed significant improvement model discrimination reclassification when compared currently standard predict incidence (C-statistic=0.82 vs. 0.79; NRI=0.325; IDI=0.036), (C-statistic=0.84 0.81; NRI=0.571; IDI=0.023), (C-statistic=0.78 0.76; NRI=0.229; IDI=0.012). Conclusion multi-ethnic population an independent predictor HF, AF, CVD. has incremental for predicting over traditional risk factors hormone levels. ClinicalTrials: gov Identifier: NCT00005487 Funding Acknowledgement Type funding sources: None.